About Amyloidosis

Overview, Disorder Types, & Improvement Prospects
A purple and cyan fibril graphicA purple and cyan fibril graphic

General Overview

Of Systemic Amyloidosis & The Patient Experience

Characterisation

Amyloid diseases are a diverse group of disorders, characterized by the deposition of amyloid protein fibrils in vital organs and tissues. There are approximately 30 different types of amyloidosis, each resulting from the misfolding and aggregation of a specific protein, and they are all severely debilitating, progressive, and often fatal.

Proven Treatments in Systemic Amyloidosis

Modulating amyloid proteins is a validated target in systemic amyloidosis. Therapies recently approved in ATTR amyloidosis have proven that reducing or stabilizing the pre-cursor protein leads to slowing disease progression. In AL amyloidosis, off-label plasma cell targeting agents including chemotherapy and Autologous Stem Cell Transplant, which both reduce the precursor protein, have also been shown to improve clinical outcomes. Reducing or stabilizing the pre-cursor protein in AL and ATTR amyloidosis results in the reduction of formation of new amyloid, but does not directly address already deposited toxic amyloid.

Diagnosis

There is a substantial unmet need to improve the diagnosis of amyloidosis in patients. The majority of systemic amyloidosis patients see more than four specialists and take more than 18 months to get an accurate diagnosis, with 25% of patients taking more than five years to get a correct diagnosis. Unfortunately, due to this prolonged process, a significant number of patients die without a diagnosis. Of the patients that do receive a diagnosis, there are a number of diagnostic procedures required with clear challenges in getting an early and accurate diagnosis. A misdiagnosis can be deadly and delayed diagnosis leads to poorer patient outcomes.

30 Subtypes

of Systemic Amyloidosis

4 Most Common Types of Systemic Amyloidosis

wtATTR
Wild-type Transthyretin Amyloidosis
Prevalence of the disease
>300K patients
in US, EU, & Japan
Disease overlaps and correlations with populations or other diseases and disorders.
13% of HFpEF patients
may have wtATTR
Common organs affected by the disease
Mainly manifests in heart and ligaments & tendons
Survival rates of the disease
Median Survival:
3-5 years
hATTR
Hereditary Transthyretin Amyloidosis
Prevalence of the disease
>50K patients
in US, EU, & Japan
Disease overlaps and correlations with populations or other diseases and disorders.
3-4% of African Americans carry the V122I (V142I) mutation
Common organs affected by the disease
Manifests in heart, nerves, GI, and kidneys
Survival rates of the disease
Median Survival: 3-15 years; 3-5 years with
cardiac involvement
AL
Light Chain Amyloidosis
Prevalence of the disease
>50K patients
in US, EU & Japan
Disease overlaps and correlations with populations or other diseases and disorders.
15-20% of MM patients have co-existing AL​
Common organs affected by the disease
Manifests in almost every organ: >70% have cardiac and/or kidney
Survival rates of the disease
Median Survival: 4 years;
6 months to 3 years
in cardiac patients
ALECT2
Leukocyte Chemotactic Factor 2 Amyloidosis
Prevalence of the disease
Unknown prevalence
Disease overlaps and correlations with populations or other diseases and disorders.
ALECT2 deposits found in~3% of Hispanic descendants
Common organs affected by the disease
Manifests mainly in kidney and liver

OtherTypes of Systemic Amyloidosis

Prevalence of the disease
Rare: <50K in aggregate
in US, EU & Japan
Common organs affected by the disease
Manifests in various organs, with about half affecting kidneys
A full list of 26 other less common types of amyloidosis

Shortcomings & Attralus Solutions

Strategies To Improve Diagnosis & Treatment

Diagnostic Pathway is Complicated

A prompt diagnosis is urgently needed, but for most patients, it takes over 18 months from first symptoms to confirmed diagnosis. For 25% of patients, it takes more than five years.

Diagnosis Lag

A significant portion of the long diagnostic timeframes is owed to an initial delay in suspicion of amyloidosis. Patients present with non-specific and seemingly unrelated cluster of symptoms such as fatigue, dyspnea, edema or GI issues. Most patients see more than four specialists before reaching a diagnosis.

An arrow pointing to the right

First-in-Class Diagnostic
Imaging Agent

The Attralus PET/CT imaging agent AT-01 has
the potential to provide a rapid and accurate diagnosis of
systemic amyloidosis.

Test Quantity,
Invasiveness, & Accuracy

Even after amyloid is suspected, the diagnostic pathway can be arduous and require numerous tests, including an invasive biopsy for most patients.  Current diagnostic tests only reveal an incomplete picture of the patient’s disease, often with amyloid
only confirmed in one organ.

An arrow pointing to the right

One Accurate,
Non-invasive Test

AT-01 has the potential to comprehensively measure amyloid deposition in organs throughout the whole body, to differentiate between subtypes of amyloidosis, and to monitor disease progression and treatment response.

Current Treatment is Limited or Non-existent for Systemic Amyloidosis

Attralus is developing novel pan-amyloid targeting agents to directly bind and remove toxic amyloid fibrils from organs and tissues throughout the body, with the potential to reverse disease pathology – going beyond current treatments that reduce the formation of amyloid fibrils and slow disease progression but do no remove amyloid from the body.

Current treatments reduce new amyloid fibril formation but do not actively remove existing toxic fibril deposits from tissues

When available, current treatment options for AL and ATTR do not directly address already deposited toxic amyloid in organs and tissues. These treatments have limited impact of later stage patients, which represent ~50% of the population.

An arrow pointing to the right

The Attralus therapeutic candidates are specifically designed to remove toxic amyloid aggregates and deposits

Attralus’s therapeutics target motifs that are universally and ubiquitously presented on all amyloid fibrils. This pan-amyloid binding profile allows Attralus’s therapeutics to target multiple types of amyloid fibrils including AL, ATTR, and ALECT2.

Only 1 out of 30 amyloid
disorders currently has
FDA-approved treatments

While there are treatments in two types of
amyloidosis (ATTR & AL), there remains a very high
unmet need with poor median survival & quality of life. 

An arrow pointing to the right

The Attralus therapeutic candidates 
can potentially address many types
of systemic amyloidosis

Not only do we have the potential to develop therapeutics to treat patients with any form of systemic amyloidosis, we also can potentially treat those with late-stage disease for whom current therapies have not shown significant impact. 

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Attralus Job

AD/Director, Program Management
Attralus, Inc., (formerly Aurora Bio) is a VC funded privately held development stage biotechnology company focused on improving the lives of systemic amyloidosis patients, through the development of novel diagnostics and therapeutics...
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AD/Director, Program Management

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Overview

Attralus, Inc., (formerly Aurora Bio) is a VC funded privately held development stage biotechnology company focused on improving the lives of systemic amyloidosis patients, through the development of novel diagnostics and therapeutics. We are developing pan-amyloid targeting agents that facilitate diagnosis, and the development of novel immunotherapies designed to clear amyloid fibrils in patients with systemic amyloid diseases. We aim to improve the diagnosis and treatment of systemic amyloid diseases, such as light chain (AL), transthyretin (ATTR), and LECT2 amyloidosis, to increase patient survival and quality of life.

Attralus’ technology has broad applications and the potential to address up to 30 systemic amyloid based diseases.  Attralus has a diagnostic imaging agent currently in a ph 1/2 trial, positioned to potentially be the first approved diagnostic specifically for amyloidosis. The company also has 2 novel therapeutic fusion proteins, directed at amyloid removal, that are in pre-clinical development

Headquartered in South San Francisco and founded in 2019, Attralus has recently completed a Series A funding with VenBio to carry forward its mission to improve the lives of systemic amyloidosis patients

Description

The AD/Director, Program Management will be responsible for providing both strategic and hands-on program and project management expertise. Initially reporting directly to the CEO, the AD/Director will be responsible for creating the program plan and budget and providing daily coordination and tracking of critical activities, assuring all milestones and deliverables are met. The Director will be responsible for developing the program management processes and procedures for the company, determining appropriate software and other tools, structuring regular meetings and communication within the company and with external collaborators.

Responsibilities

Collaborate with the management team to provide project management leadership and execution activities within the company and between external partners and Attralus teams.

Develop and execute integrated cross-functional project plans with established goals, milestones, timelines and budget, with a key focus on bringing pre-clinical therapeutic programs into early clinical development

Conduct and direct day-to-day program activities to meet milestones; monitoring critical path activities to ensure delivery of program objectives.

Drive planning for key drug development milestones.

Maintain effective communication with the management team through oral and written correspondence and ensure adequate documentation of each communication. 

Always use/model/maintain/promote best practices in Program Management, including the use of agendas, minutes, dashboards, maintain document repository, establish and implement templates, tools, and processes to drive efficiency, alignment, communication, and effective planning.

Create and maintain easily accessible, high level program documents in electronic format. 

Recommend, manage and train on necessary software and tools.

Identify, develop and/or maintain an appropriate electronic platform (SharePoint, Shared Folders, etc.) for reporting/archiving/documentation of relevant program information, records, etc. 

Conduct risk management, contingency and scenario planning using appropriate program management tools.

Identify program issues or resource gaps and facilitate resolution.

Communicate program information and support development of program presentations to senior leadership, board members, investors and other key stakeholders as appropriate.

Contribute to budgetary planning at the program level.

Facilitate adherence to Aurora’s governance processes; work with key stakeholders to prepare for those interactions; lead/support as appropriate. Ensure implementation of governance decisions.

Qualifications

Minimum of a BA/BS in a scientific disciplined is required, Advance degree preferred

7+ years of program management or equivalent experience in a pharmaceutical or biotechnology organization.

Experience with research/pre-clinical and early clinical development project planning required. PM Certification is a plus.

Rare disease experience a strong plus (not required).

Desire and ability to work in a start-up, fast paced organization where you will wear many hats.

Must have excellent verbal and written communication skills as well as exceptional organizational capability.

Ability to drive program plans and timelines (across multiple functional areas) is essential.  Proven success in goal setting, prioritization and time management is required.

Understanding of FDA and/or EMA quality and regulatory processes. Prior experience with regulatory filings is desirable. 

Experience working with external partners is desirable.

Ability to work independently in decision-making and resolution of program obstacles and conflicts.

Familiarity with developing budgets and forecasting is desirable.

Ability to function autonomously, with an appreciation of detail while being cognizant of “the big picture.”

Have a patient-first mindset. All decisions made with patients in mind.

Proficiency with Microsoft Word, Excel, PowerPoint, and Project is required.

Benefits/Equal Opportunity Employer

Attralus, Inc. offers both comprehensive benefits and Paid Time Off (PTO) plans for employees, which begin on the first day of employment.

Attralus, Inc. is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

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